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Detect-ME

EndoSign Cell Collection Device Study

Our office

Detect-ME

EndoSign Cell Collection Device Study

Our office

Detect-ME

EndoSign Cell Collection Device Study

Study Overview

Study Name:
Detect-ME: Detection and Monitoring of Barett's Esophagus and Esophageal Neoplasia Using Methylation Biomarkers on Endosign Cell Collection Device

Purpose:
The goal of this study is to help develop a convenient diagnostic test that can be conducted in a clinic to detect and monitor conditions such as GERD and Barrett’s esophagus to prevent esophageal cancer. The study is sponsored by Cyted Health.

Eligibility:
Individuals with known Barrett's esophagus (a documented history of >1 cm BE), with a surveillance endoscopy scheduled.

or

Individuals with chronic reflux (GERD) scheduled for a high-risk screening (initial endoscopy) looking for Barrett's esophagus and at least 3 or more additional risk factors including:

  • Age ≥ 50

  • Family history of Barrett’s or esophageal cancer

  • Current or Former Smoker

  • Obesity

  • Male

  • Non-Hispanic White

Both individuals must be willing to undergo non-endoscopic sampling with the study device prior to EGD (up to 6 weeks prior to EGD or day of EGD).

Participation:
Participation would consist of coming in to a nearby research clinic where you would swallow a small capsule similar in size to a vitamin pill. The capsule contains a tiny sponge attached to a surgical thread, which the clinician would then gently retrieve collecting cells from the entire length of your esophagus. The actual procedure can be completed in less than 20 minutes and there is no need for sedation.

Compensation:
Participants will receive $100 for their time after completing their participation in the study.

Our Model

Participating is simple

1

Chat with a Study
Coordinator

Chat with a Study
Coordinator

A brief phone conversation with one of our study coordinators will quickly determine if you meet the eligibility criteria for the study.

A brief phone conversation with one of our study coordinators will quickly determine if you meet the eligibility criteria for the study.

2

Review and Sign an Informed Consent Form

Review and Sign an Informed Consent Form

If you meet the eligibility requirements, the coordinator will guide you through the Informed Consent answering any questions you may have. The clinic team will then contact you to schedule your appointment at a convenient location.

If you meet the eligibility requirements, the coordinator will guide you through the Informed Consent answering any questions you may have. The clinic team will then contact you to schedule your appointment at a convenient location.

3

Take the Test at a Nearby Clinic

Take the Test at a Nearby Clinic

You will be asked to swallow a small capsule similar in size to a vitamin pill with a cup of water. The capsule contains a tiny sponge attached to a surgical thread. After a few minutes, the clinician will then gently retrieve it. After a brief survey, you're done.

You will be asked to swallow a small capsule similar in size to a vitamin pill with a cup of water. The capsule contains a tiny sponge attached to a surgical thread. After a few minutes, the clinician will then gently retrieve it. After a brief survey, you're done.

4

Attend Your Endoscopy as Scheduled

Attend Your Endoscopy as Scheduled

Simply attend your appointment with your physician as scheduled.

Simply attend your appointment with your physician as scheduled.

We are committed to empowering patients and clinicians to participate in making clinical research more accessible, inclusive and impactful.

We are committed to empowering patients and clinicians to participate in making clinical research more accessible, inclusive and impactful.

What to Expect

man in white dress shirt holding white box
man in white dress shirt holding white box

How big is the capsule?

How big is the capsule?

How big is the capsule?

The capsule is about the size of a vitamin pill and contains a sponge connected to a thin, strong surgical thread.

How does the testing work?

How does the testing work?

How does the testing work?

1. You will be asked to swallow the capsule with 1 or 2 cups of water.

1. You will be asked to swallow the capsule with 1 or 2 cups of water.

man in white dress shirt holding white box
man in white dress shirt holding white box

2. The capsule dissolves when it reaches your stomach, releasing the sponge. This takes 7 minutes.

3. The clinician will then gently pull the thread, and the sponge will collect cells as it passes through your esophagus. This part only takes a few seconds. Because it collects cells from the entire length of the esophagus, it covers a larger area than a traditional biopsy.

3. The clinician will then gently pull the thread, and the sponge will collect cells as it passes through your esophagus. This part only takes a few seconds. Because it collects cells from the entire length of the esophagus, it covers a larger area than a traditional biopsy.

person holding pencil near laptop computer
person holding pencil near laptop computer
man in white dress shirt holding white box
man in white dress shirt holding white box

Are there any risks?

There have been no serious side effects reported and in over 7,500 uses, there have been zero instances of the sponge detaching from the string. Most people have no issues swallowing the capsule, but the test will be stopped if you experience any problems or discomfort. Some people may have a mild sore throat after the test, but this usually goes away within 48 hours.

Is it uncomfortable?

Is it uncomfortable?

Most people have no issues swallowing the capsule, but the test will be stopped if you experience any problems or discomfort. Some people report gagging as the sponge is retrieved and may have a mild sore throat after the test, but this usually goes away within 48 hours.

Most people have no issues swallowing the capsule, but the test will be stopped if you experience any problems or discomfort. Some people report gagging as the sponge is retrieved and may have a mild sore throat after the test, but this usually goes away within 48 hours.

person holding pencil near laptop computer
person holding pencil near laptop computer

FAQs

Frequently Asked Questions

Who is Aton Health?

Aton Health was created to help accelerate the advancement of screening and early detection for cancer & chronic disease by providing turnkey clinical trial participation opportunities to clinicians with, and without, existing research capabilities.

What is the relationship between Aton Health and my physician?

Aton Health empowers clinicians, like your doctor, to play a leadership role in observational research focused on advancements in cancer and chronic disease screening and early detection. Aton Health works closely with your doctor to accelerate early diagnosis through strategic partnerships, innovative tools and scalable solutions for improved patient outcomes.

Why does my participation matter?

Clinical research is essential to discovering more accurate ways to detect cancer sooner—often before symptoms appear—when treatment is most effective. By participating, you contribute to advancing medical knowledge and outcomes for future generations, all while remaining under strict ethical protections to ensure privacy.

Who is Aton Health?

Aton Health was created to help accelerate the advancement of screening and early detection for cancer & chronic disease by providing turnkey clinical trial participation opportunities to clinicians with, and without, existing research capabilities.

What is the relationship between Aton Health and my physician?

Aton Health empowers clinicians, like your doctor, to play a leadership role in observational research focused on advancements in cancer and chronic disease screening and early detection. Aton Health works closely with your doctor to accelerate early diagnosis through strategic partnerships, innovative tools and scalable solutions for improved patient outcomes.

Why does my participation matter?

Clinical research is essential to discovering more accurate ways to detect cancer sooner—often before symptoms appear—when treatment is most effective. By participating, you contribute to advancing medical knowledge and outcomes for future generations, all while remaining under strict ethical protections to ensure privacy.

Who is Aton Health?

Aton Health was created to help accelerate the advancement of screening and early detection for cancer & chronic disease by providing turnkey clinical trial participation opportunities to clinicians with, and without, existing research capabilities.

What is the relationship between Aton Health and my physician?

Aton Health empowers clinicians, like your doctor, to play a leadership role in observational research focused on advancements in cancer and chronic disease screening and early detection. Aton Health works closely with your doctor to accelerate early diagnosis through strategic partnerships, innovative tools and scalable solutions for improved patient outcomes.

Why does my participation matter?

Clinical research is essential to discovering more accurate ways to detect cancer sooner—often before symptoms appear—when treatment is most effective. By participating, you contribute to advancing medical knowledge and outcomes for future generations, all while remaining under strict ethical protections to ensure privacy.

Questions?

Just a tiny amount of your time could make a big difference.

Click the link below to schedule a brief call with a study coordinator.

Just a tiny amount of your time could make a big difference. Click the link below to schedule a brief call with a study coordinator.

Let's Talk

Let's Talk

Let's Talk